Cellular temperature compensation of sensory receptor neuron responses

Cell-intrinsic mechanisms of temperature compensation in a grasshopper sensory receptor neuron

Changes in temperature affect biochemical reaction rates and, consequently, neural processing. The nervous systems of poikilothermic animals must have evolved mechanisms enabling them to retain their functionality under varying temperatures. Auditory receptor neurons of grasshoppers respond to sound in a surprisingly temperature-compensated manner: firing rates depend moderately on temperature,...

Spinal Sensory Projection Neuron Responses to Spinal Cord Stimulation Are

Vesicular Diversity and Crowding within the Olfactory Sensory Receptor Neuron

The olfactory sensory receptor neuron (OSRN) is an important cellular component of the vertebrate olfactory system that are responsible for detection and discrimination of different type of chemical cues from the external environment [1]. The neural communication between the sensory receptor cells is generally mediated through vesicles [2]. The fine structural details of OSRN aim to unfold the ...

Temperature dependency of P2 receptor-mediated responses.

The P2 receptor-mediated responses of isolated guinea pig urinary bladder and vas deferens (P2X receptors) and taenia caeci (P2Y receptors) were registered at the three temperature conditions of 30, 37 and 42 degrees C. The contractile responses of both urinary bladder and vas deferens to a P2X receptor agonist alpha,beta-methylene ATP (alpha,beta-meATP; 0.01-30 microM) and to electrical field ...

Optimal compensation for neuron death

The brain has an impressive ability to withstand neural damage. Diseases that kill neurons can go unnoticed for years, and incomplete brain lesions or silencing of neurons often fail to produce any effect. How does the brain compensate for such damage, and what are the limits of this compensation? We propose that neural circuits optimally compensate for neuron death, thereby preserving their fu...